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Figure 2: The pineal glands anatomical position within the neuroendocrine hub explains its outsized influence on circadian, immune, and hormonal systems, making Epitalons tissue-specific action particularly significant

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[Google Scholar] 82.Ruenzi M., Stolte M., Veljaca M., Oreskovic K., Peterson J., Ulcerative Colitis Study Group A multicenter, randomized, double blind, placebo controlled phase II study of PL 14736 enema in the treatment of mild-to-moderate ulcerative colitis

Other routes of administration (including inhaled and topical: dental-intracanal, dermal, intranasal, ophthalmological and perianal) are not prohibited when used within the manufacturers licensed doses and therapeutic indications

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[DOI] [PMC free article] [PubMed] [Google Scholar] [96].Wang H, Lu M, Zhai S